Bench to Bedside: Future Therapies For Treatment Of Anemia In Patients With Chronic Kidney Disease
Authors
KM Murali
Abstract
The link between chronic kidney disease (CKD) and anaemia has been known for over 180years ever since it was highlighted by the legendary Richard Bright. The key aetiological factors responsible for anaemia due to renal disease were identified in the 1950s as relative deficiency of erythropoietin and reduced red cell survival as well as abnormalities in iron metabolism. This knowledge was not translated to therapeutics for the next three decades and red cell transfusions were the main-stay of treatment of renal anaemia till recombinant human erythropoietin (rHuEPO) was introduced in the 1980s.
Author Biography
KM Murali
Senior Staff Specialist & Clinical Associate Professor,
Wollongong Hospital & University of Wollongong