Endocrinology Of Aging

Abstract

Changes occurring in the human body is programmed from womb to tomb at the time of conception. Changes in every body systems follow this programme. Changes related with aging cannot be prevented, but can be modified. It is also noted that there is individual differences in the aging process and it is not decided by  chronologic age alone. This is due to  many factors  like genetic, environmental and lifestyle. With daily functioning, there is constant damage in every cells. This is less important  in cells which do not replicate in postnatal life. Processes like DNA repair partly overcome this cellular damage but the repair process lag behind damage as the age advances. In case of cells which replicate rapidly like intestinal epithelium and blood cells, this may be relevant. Repeated multiplications cause DNA damage and mitogenicity and reflected in  the length of telomeres of the chromosomes with advancing age.