Familial Hepatocellular Carcinoma In A Non Hepatitis B Endemic Area: A Case Report And Review Of Literature

Abstract

Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide. The majority of the cases are Hepatitis B or C virus (HBV, HCV) related. Familial clustering of HCC is known in HBV endemic areas. There are also genetic alterations which have been identified in families with HCC in non endemic areas. We report such a family of two siblings diagnosed with HCC at a young age who presented to us. One patient had incurable disease and the other patient underwent curative surgery. We also review relevant literature of familial HCC through this case report.