Neurology

• MBBS - JN Medical college Belgam
• MD GENERAL MEDICINE - Mysore Medical college, Mysore
• DM NEUROLOGY - Stanley Medical College, Chennai

• 1974 – 1975: Senior Resident in Medicine, Medical College Hospital, Calicut India
• 1975 – 1978: Post graduate trainee, Govt. Medical College, Mysore, India
• 1978 – 1980: Consultant Physician, Health Dept. Govt. of Kerala, India
• 1983 – 1987: Lecturer in Neurology, Medical College Hospital, Calicut, Kerala
• 1987 – 1993: Chief Neurologist, Baby Memorial Hospital, Calicut, Kerala
• 1993 – 1995: Chief Resident in Neurology, Salmaniya Medical Centre, Bahrain, Arabian Gulf
• 1995 - SEP 2017: Consultant Neurologist, Chairman, Division of neuron Sciences, Baby Memorial Hospital, Calicut, Kerala
• SEP 2017 -JUN 2022: Chairman, Division of neuron Sciences, Meitra Hospital Calicut
• JUL 2022 – Till Date: Senior consultant neurologist, Baby Memorial Hospital, Calicut

• Around 30 papers and presentation in National and International Journals and meetings.

• PRoFESS Trial
• VITATOPS trial - All are international Trials related to stroke
• Inter stroke trail
• Interact -2
• Kerala Einstein study on Dementia (Founded by National Institute of Health, USA)

• M.B.B.S from Calicut Medical College 1987
• MD in Internal medicine from KMC Mangalore 1992
• DM in Neurology from Kottayam Medical college 2000
• Training in interventional Neurology from Sir Ganga Ram Hospital 2007 to 2008
• Professional diploma in clinical research 2013
• FRCP(Glasg)- Fellow of Royal College of Physicians.
• FAAN - Fellow of the American Academy of Neurology.
• FEAN - Fellow of European Academy of Neurology.
• FIMSA- Fellowship in International Medical Sciences Academy.
• FRCP(Edin)- Fellow of Royal College of Physicians.

• Private Practice as internist at Edappal Hospital from 1992 to 1995 and at AL-RAYAN poly clinic, Saudi Arabia from 1995 to 1997.
• Sub specialization in Neurology at Kottayam Medical college – 1997-2000
• Senior lecturer in Neurology at Calicut Medical College- 2001
• Working since 2000 at Baby Memorial Hospital

Principal investigator (PI)

• Parkinson's study (Safinamide)- (3rd Largest recruitment in India) 2006 - 2008 : Screened 31 patients and 19 randomized patients
• Low back pain Study (Ralfinamide) and extension study 2009 : 14 Patients Randomized
• Parkinson study extension 2008 - 2010 : Randomized 15 patients
• Study on Rotigotine patch 2011 - 2012 : Randomized 8 patients
• Study on pediatric migraine 2010 : Screened 5 patients
• Inspire Stroke epidemiological study 2012 - 2014 : 150 patients
• Interact 2 study on intracerebral hemorrhage : 2011 with 14 Patients
• Study on pramipexole-PK study 2014 : Screened 4 patients, randomized 1 patient
• Study on acitrom (CONFIDENCE-REGISTRY 2015) 2015 : 74 patients
• Head Post Trial international study (George institute, Australi 2016 - 2017 : 70 Patients
• IRIS- TNK Registry 2018 : 15 Patient
• Clinical study to assess Efficacy of PMZ-1620 along with standard treatment in patients of Acute Ischemic Stroke --reg, Phase 3 randomised trial 2020.(On Going)

Co-Investigator

• Vitatops - 2016: Randomized 100 patients(Co-I)
• Inter stroke - 2006: 100 patients(Co-I)
• Multiple sclerosis - 2009: Screened 2 patients(Co-I)
• Sits - New study on IV tPA: 30 patients(Co-I)
• Tnk-tpa study: 8 patients(Co-I)

Ongoing studies

• Epilepsy and pregnancy - Teratogenicity and anti epileptic drugs - Since 2014 Vit B12 and pain syndrome - Since 2014
• Samarpanam study (Epidemological study on stroke and other life style diseases and Risk factors - Since 2017
• Epidemiological study of risk factors of stroke( Indian Academy of Neurology Research Grant Pending) - 2020

• Hypercalcemia and secondary hypoparathyroidism following over- the counter Vitamin D intoxication---- JIMSA manuscript for publication April 1 2020(in print) Ummer Karadan, Robin George Manappallil
• Dissecting an outbreak :A Clinico epidemiological study of Nipah virus infection in Kerala ,India 2018 .Bhargavan Pallivalappil,Althaf Ali, NK Thulaseedharan, Ummer Karadan , Jayakrishnan Chellenton ,KP Dipu,AS Anoop Kumar, KG Sreejith Kumar, TP Rajagopal, KP Suraj,GR Santosh Kumar, RN Supreeth,Mounika Velisetti,Prathap Reddy Muthalya, KS Aryasree, K.S.Apurva Rao, ( ORIGINAL RESEARCH ARTICLE )
• Nipah Virus Infection with cerebellar dysfunction --European journal of Medical case reports February 1 2020- --Bhargavan Pallivalappil,Ummer Karadan , Jayakrishnan Chellenton ,Robin George Manappallil.
• Isolated Horner syndrome as a sole manifestation of ischemic stroke -----EC Neurology case Report April 29 2019 Deep as ,Ummer Karadan,Jayakrishnan Chellanton and Manoj KS Mahata
• Multiple sclerosis presented as isolated peripheral facial nerve ------ Indian Journal of Clinical Report ---Ummer Karadan, Robin George Manappallil,Revathy Aril. The IVY sign of Moya Moya disease. Ummer Karadan, Robin George. Asian Journal of Medical sciences . 01-05-2019
• Bilateral lateral geniculate body lesions causing reversible blindness in a patient with posterior reversible encephalopathy syndrome.Ummer Karadan, Suprith R.Naga, Jayakrishnan .J R Coll physicians Edinb 2019;49:34-6.
• Trigeminal Trophic Syndrome following anterior inferior cerebellar artery infarction. Ummer karadan , Robin george manapallil, Anisha janardhanan,Ramesh naga supreeth-BMJ case reports -2018 ( ICCREEE- Certificate of expertise , Special apreciation from Pubindex International )
• A.Neurointervension in Nepalese Neurosciences practice:The need of the hour Paudel R,Phuyal S ,B. Dopamine Treatment in Acute Ischemic Stroke ,Ummer Karadan, 2018 (ORIGINAL ARTICLE)
• Pontine haemorrhage disguised as Bell’s palsy-february 2018 -Ummer Karadan, Robin George Manapallil, chellenton Jayakrishnan, Ramesh Naga Supreeth-BMJ case reports -2018
• Rhabdomyolysis: a rare complication of Hashimoto’ s thyroiditis precipitated by statin therapy february 2018 -Jayameena peringat, Robin George Manappallil, Ummer Karadan - BMJ case reports - 2018
• Twenty-Four Syndrome: An Untold presentation of Pontine Hemorrhage.Ummer Karadan, DM (Neurology), Robin George Manappallil, MD,Ramesh N.Supreeth,MBBS and Chellenton Jayakrishnan,DM(Neurology),J Stroke cerebrovasc Dis -2018
• Pontine infarct masquerading as Bell’ palsy, a case report , Journal of case report 2017 , Ummer Karadan, Robin George -et al
• A Case of Hybrid Carotid Revascularization. BMH Medical Journal - ISSN 2348–392X, [S.l.], v. 4, n.2, p. 65-68, feb. 2017. ISSN 2348-392X, Hari Prasad, Ummer Karadan, et al.
• Hypercalcemia following over-the counter Vitamin D intoxication in an elderly debilitated patient. European Geriatric Medicine. 10.1016/j.eurger.2017.03.004. Ummer Karadan & George, Robin. (2017)
• R.G. Manappallil, Ummer Karadan, P. Kumar, M.C. Sabir, R.N. Supreeth, Acute delirium following administration of Piperacillin-Tazobactam in an elderly patient with chronic liver disease, In European Geriatric Medicine, Volume 8, Issue 4, 2017, Pages 285-286, ISSN 1878-7649
• Ummer Karadan; DESAI, Nagaraj Ashok. Eosinophilic Meningitis in a Middle Aged Man After Consumption of Camel Meat. BMH Medical Journal - ISSN 2348–392X, [S.l.], v. 1, n. 2, p. 30-32, mar. 2014.
• Intravenous thrombolysis for acute ischemic stroke in the 3- to 4·5-hour window - the Malabar experience.-Dr Salam KA1, Ummer Karadan, Pradeep Kumar VG, Noone ML- Int J Stroke. 2014 Jun;9(4):426-8. (ORIGINAL ARTICLE)
• Ummer Karadan, Salam KA, Noone ML, Pradeep Kumar VG, Mampilly N, Sivakumar S. Leukoencephalopathy with intracranial calcifications and cysts in an adult: Case report and review of literature. Annals of Indian Academy of Neurology. 2010;13(4):299-301
• Noone ML, Kumar VG, Ummer Karadan, Achambat L, Salam KA. Cirrhosis presenting as Parkinsonism. Ann Indian Academy Neurology. 2008 Jul;11(3):179-81.
• Salam KA, Ummer Karadan, Kumar VG, Noone ML, Laila A, Ragini J. Intravenous thrombolysis for acute ischemic stroke: the Malabar experience 2003 to 2008. J Clin Neuroscience. 2009 Oct;16(10):1276-8. ( ORIGINAL ARTICLE)
• Clinical and etiological profile of tropical ataxic neuropathy in Kerala, South India. Madhusudanan M1, Menon MK, Ummer Karadan, Radhakrishnanan K. Acta Scandenevia EUR.Neurol. 2008;60(1):21-6.( Original article)
• Isolated hypoglossal paralysis following Orofacial herpes simplex infection -Journal of Association of physicians of India -1995 JAPI VOL 43, Praveen K, Ummer Karadan

• MBBS from Calicut Medical College 1993
• MD from Calicut Medical College 1997
• DM from AIIMS, New Delhi ­ 2002
• DNB ­ 2003
• MNAMS ­ 2004

• 18 years experience in Neurology practice.

• Intravenous Thrombolysis for acute Ischemic Stroke in the 3­ to 4·5 ­hour window – the Malabar experience; 2013 The Authors. International Journal of Stroke 2013 World Stroke Organization; 2013.
• Objective Cardiac markers in Dementia: Results from the Kerala–Einstein Study; International Journal of Cardiology (2012).
• Cirrhosis presenting as Parkinsonism; Annals of Indian Academy of Neurology – July­September 2008.
• Potentially Inappropriate Medication use in individuals with Mild Cognitive Impairment: Results from the Kerala Einstein Study; Letter to the Editor; JAGS July 2012; Vol 60; No. 7.
• Leukoencephalopathy with intracranial calcifications and cysts in an adult: Case report and review of literature; Annals of Indian Academy of Neurology, October- December 2010, Vol 13, Issue 4.
• Intravenous Thrombolysis for acute ischemic stroke: The Malabar experience 2003 to 2008; Journal of Clinical Neuroscience; 16 (2009) 1276–1278.

• DM from Madras Medical College.
• MD from Kerala University.
• MBBS from Kerala University.

• Now working as the Senior Consultant Neurologist at Baby Memorial Hospital for the past 3 years.
• Worked for 3 years after post retirement from Calicut Medical College as Prof of Neurology at CMC, Vellore, TamilNadu.
• HOD of Neurology at Medical College, Calicut for 15 years from 1990 till retirement in 2005.
• Worked as Tutor, Asst Prof, Associate Prof and Prof in Kottayam, Alappuzha and Calicut Medical Colleges respectively.
• Had been an Examiner for DM Neurology at various universities in Kerala, National Institutes like SCTMC, NIMHANS, MGR University, Tamil Nadu.

• Has presented papers in national and international conferences. Chaired sessions in various conferences in addition to conducting several CME programmes. There are many publications to her credit in national and a few international journals.

• Was awarded the MM Ghini award for the best college teacher of the Calicut University in 2002.

• D.M. in Neurology from National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India. August, 2007
• M.D. in Internal Medicine from Medical College, Kottayam. December, 2003
• M.B.B.S. from Medical College, Calicut. 1999

• Senior Resident, Department of Neurology at National Institute of Mental Health and Neurosciences, Bangalore, India ­ from December 2004 to December 2007.
• Consultant Neurologist,Baby Memorial Hospital, Calicut, Kerala ­ from December 2007 to present (current position).
• Observer, Comprehensive Epilepsy Program, Wayne State University / Detroit Medical Center, Detroit, USA from September to November 2008.

• George M, Noone ML, Santhosh P, Santhoshkumar R, Sagar BKC and Mahadevan A. Skin biopsy as an aid to diagnosis of disorders of the nervous system without cutaneous manifestations. Int J Dermatol. 2021. https://doi.org/10.1111/ijd.15513
• Noone ML, Moideen F, Krishna RB, Pradeep Kumar VG, Karadan U, Chellenton J, Salam KA. Mobile App Based Strategy Improves Door-to-Needle Time in the Treatment of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2020;29(12):105319. doi: 10.1016/j.jstrokecerebrovasdis.2020.105319.
• Rajesh MC, Noone ML, Harish Babu PS. Epidural blood patch for spontaneous intracranial hypotension. Natl Med J India. 2019;32:288-289
• Noone ML, Moideen F. Mobile apps: an emerging tool to improve acute stroke care. J R Coll Physicians Edinb. 2019;49: 3-4
• Chandrasekhar DP, Noone ML, Babu SPH, Bose VTC. Magnetic resonance imaging findings in brain resulting from high-voltage electrical shock injury of the scalp. Indian J Radiol Imaging. 2018;28:312
• Salam KA, Rafeeque M, Hashim H, Mampilly N, Noone ML. Histology of Thrombectomy Specimen Reveals Cardiac Tumor Embolus in Cryptogenic Young Stroke. J Stroke Cerebrovasc Dis. 2017 Dec 12. doi: 10.1016 / j.jstrokecerebrovasdis. 2017.11.015.
• Salam KA, Noone ML, Hashim H. Endovascular Treatment For Acute Anterior Circulation Ischemic Stroke-New Evidence And Current Status. BMH Medical Journal. 2016; 3 (3)
• Wang N, Allali G, Kesavadas C, Noone ML, Pradeep VG, Blumen HM, et al. Cerebral small vessel disease and motoric cognitive risk syndrome: results from the Kerala-Einstein Study. J Alzheimers Dis. 2016;50(3):699-707.
• Salam KA, Ummer K, Pradeep Kumar VG, Noone ML. Intravenous thrombolysis for acute ischemic stroke in the 3- to 4•5-hour window--the Malabar experience. Int J Stroke. 2014;9:426-8
• Nair V, Ayers E, Noone M, Johnson B, Verghese J J Am Geriatr Soc. 2014 Jan;62(1):197-9.
• Verghese J, Annweiler C, Ayers E, Barzilai N, Beauchet O, Bennett DA, Bridenbaugh SA, Buchman AS, Callisaya ML, Camicioli R, Capistrant B, Chatterji S, De Cock AM, Ferrucci L, Giladi N, Guralnik JM, Hausdorff JM, Holtzer R, Kim KW, Kowal P, Kressig RW, Lim JY, Lord S, Meguro K, Montero-Odasso M, Muir-Hunter SW, Noone ML, Rochester L, Srikanth V, Wang C. Motoric cognitive risk syndrome: multicountry prevalence and dementia risk. Neurology. 2014;83:718-26.
• Mohan Leslie Noone. Anti GAD65 Encephalopathy Presenting with Reversible Encephalopathy and Orofacial Dyskinesias. BMH Med. J.2014;1(2):33-¬36
• Verghese J, Noone ML, Johnson B, Ambrose AF, Wang C, Buschke H, Pradeep VG, Abdul Salam K, Shaji KS, Mathuranath PS. Picture-based memory impairment screen for dementia. J Am Geriatr Soc. 2012;60:2116-20
• Tsai R, Noone M, Johnson B, Pradeep VG, Verghese J. Potentially inappropriate medication use in individuals with mild cognitive impairment: results from the Kerala Einstein Study. J Am Geriatr Soc. 2012;607:1369-70.
• Ambrose AF, Noone ML, Pradeep VG, Johnson B, Salam KA, Verghese J. Gait and cognition in older adults: Insights from the Bronx and Kerala. Annals of Indian Academy of Neurology 2010;13(Suppl 2):S99-S103.
• Ummer K, Salam KA, Noone ML, Pradeep Kumar VG, Mampilly N, Sivakumar S. Leukoencephalopathy with intracranial calcifications and cysts in an adult: Case report and review of literature. Annals of Indian Academy of Neurology 2010;13:299-301.
• Salam KA, Ummer K, Pradeep Kumar VG, Noone ML, Laila A, Ragini J. Intravenous Thrombolysis for Acute Ischaemic Stroke - The Malabar Experience 2003 to 2008. Journal of Clinical Neuroscience 2009;16:1276–1278.
• Bindu PS, Noone ML, Nalini A, Muthane UB, Kovoor JM. Biotin-Responsive Basal Ganglia Disease: A Treatable and Reversible Neurological Disorder of Childhood. Journal of Child Neurology 2009;24:750-752.
• Srivastava A, Taly AB, Gupta A, Murali T, Noone ML, Thirthahalli J, Gangadhar BN, Kumar JK, Jayakumar PN. Stroke with supernumerary phantom limb: case study, review of literature and pathogenesis. Acta Neuropsychiatrica 2008;20:256-64.
• Noone ML, Pradeep Kumar VG, Ummer K, Salam KA, Laila A. Cirrhosis Presenting as Parkinsonism. Annals of Indian Academy of Neurology 2008;11:179-81.
• Nagaraja D, Noone ML, Bharatkumar VP , Christopher R. Homocysteine, Folate And Vitamin B12 In Puerperal Cerebral Venous Thrombosis. Journal of Neurological Sciences 2008;272: 43-7.
• Deepti AN, Noone ML, Mahadevan A, Naresh KN, Yasha TC, Satishchandra P, Muthane UB, Shankar SK. Primary Cardiac Cytotoxic T-cell Lymphoma Presenting with neurological deficits - a case report. Cardiovascular Pathology 2008;17:334-8
• Noone ML, Sinha S, Taly AB, Chandrika S. Periodic lateralized epileptiform discharges in neurosyphilis. Epilepsia 2007;48: 390-3.

• Winner of National Talent Search Scholarship awarded by National Council for Educational Research and Training - 1992
• Gold Medal: National Standard Examination in Chemistry – 1994
• First Prize: All­India Apollo Annual Medical Quiz, Chennai – 1998

• MBBS
• MD (General medicine)
• DNB(Neurology)
• DM in Neurology
• Fellowship in Movement disorder

• Parkinsonism
• Deep brain stimulation
• Botulinum toxin therapy
• Tremor disorders
• Balance disorders
• Post-stroke spasticity
• Tics, chorea, and dystonia
• Management of stroke, Epilepsy, Headache, and neuropathy

• Professor & Head of Neurology and Director, James Parkinson’s Movement Disorder Centre. Kannur Medical College.
• Published 26 articles in international peer-reviewed journals
• Guide to students of University of Gothenburg, Sweden
• Research collaboration with University of British Columbia, Canada, University of Orebro, and University of Gothenburg, Sweden
• Editor-in-chief of International Journal of Modern Medicine One of the founding members of the Movement Disorder Society in India.

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